Independent Confirmation Of Our Micronutrient Research

  1. The independent confirmation of our micronutrients research in the area of immune function and immune deficiency diseases has already been comprehensively documented in Section A of this affidavit. In a similar way, a growing number of research and clinical studies are confirming our scientific research in the fields of cardiovascular disease and cancer.
  2. Following are examples of such publications documenting the health benefits of micronutrients in various areas of human health. This section of my affidavit is particularly important, because it disqualifies any effort by the Applicants to discredit our research as “charlatanry.” To the contrary, the extensive list of independent confirmation of the health value of micronutrients solidifies the role of our research Institute as scientific leaders and “pioneers” in micronutrient research and science-based natural health.
  3. Independent scientific confirmation about the health benefits of vitamins in disease prevention in general:
    1. “The Nobel Prize and the Discovery of Vitamins.”
      As detailed above, the official website of the Nobel Prize Committee summarizes the Nobel Prizes awarded for vitamin research and the relation of micronutrients for maintaining human health. (Annexure ‘Nobel Prize Vitamins’).
    2. “Vitamins for Chronic Disease Prevention in Adults.”
      This “Scientific Review” was published in the official journal of the “American Medical Association” (JAMA) on June 19, 2002 (Annexure ‘JAMA 2002’).
      1. This landmark publication in JAMA marked a turning point in the century long history of the “American Medical Association”. It concludes – among others: “Inadequate intake of several vitamins has been linked to chronic diseases, including coronary heart disease, cancer, and osteoporosis.”
      2. This publication determined a policy shift for the “American Medical Association” which, since that time, officially recommends micronutrients supplementation to all physicians in the US as part of their medical practice.
      3. In the context of this litigation it is noteworthy that the “American Medical Association (AMA)”, is the counterpart of the “South Africa Medical Association (SAMA)”. While the “American Medical Association” is recommending to more than 200,000 doctors in the USA to help improve the health of their patients by recommending micronutrients, the leadership of the “South Africa Medical Association” is fighting the dissemination of information about the preventive and therapeutic health benefits of vitamins via this Application.
  4. Independent scientific confirmation related to the health benefits of micronutrients in fighting cancer:
    1. Confirmation for the significance of my discoveries at the molecular level
      Recently the cellular mechanisms used by viruses and cancer cells to spread – the primary target of our research efforts – was independently confirmed by a group of scientists from the University of Copenhagen ( Denmark ). In a unique experiment in animals they “knocked out” the genes responsible for producing the collagen-digesting enzymes – the “biological scissors” - described above. By taking away these “tools” for the spread of cancer cells (as well as viruses and many other infections), the rate of these animals to develop metastasizing cancer decreased significantly compared to the control group. This confirms at the genetic level – i.e. in a scientifically undisputed manner – the importance of these mechanisms in controlling the spread of cancer – and potentially many other diseases (Annexure ‘Almholt et al 2004’).
    2. “Pharmacologic Ascorbic Acid Concentrations Selectively Kill Cancer Cells.”
      This study was published by a group of researchers from the National Institutes of Health (USA) and published in the “Proceedings of the National Academy of Science, USA” in September 2005. The study concluded “These findings give plausibility to intravenous ascorbic acid [vitamin C] in cancer treatment, and have unexpected implications for treatment of infections …” (Annexure ‘PNAS Study’).
    3. Two studies documenting the health benefits of polyphenols in blocking cancer cell multiplication and spread
      Polyphenols are a group of natural substances extracted from Green tea, grapes, pomegranate and certain other plants and extensively studied at the Dr Rath Research Institute. These independent studies were conducted at the University of Wisconsin in Madison , USA , and the University of Hamburg, Germany, respectively, and were published in the “Proceedings of the National Academy of Sciences”, and the “Journal of Biological Chemistry” - two of the world’s leading scientific journals. Both studies come to the same conclusion and comprehensively confirm the research findings from our Institute: Polyphenols are effective and safe natural molecules that can selectively inhibit the spread of cancer cells (Annexures ‘J Biol Chem’, ‘PNAS’).
    4. “Are Vitamin and Mineral Deficiencies a Major Cancer Risk?”
      This scientific review published in the leading scientific journal “Nature” on September 12, 2002 , concludes: “Optimizing vitamin and mineral intake by encouraging dietary change, multivitamin and mineral supplements, and fortifying foods might therefore prevent cancer and other chronic diseases” (Annexure ‘Nature’).
  5. Documented Health Benefits of Micronutrients in Cardiovascular Disease:
    In a similar way, a growing amount of scientific evidence and clinical studies confirm the health benefits of micronutrients in the prevention of cardiovascular disease:
    1. “Serial coronary angiographic evidence that antioxidant vitamin intake reduces progress of coronary artery atherosclerosis.”
      This study conducted at the Division of Cardiology, University of Southern California School of Medicine, Los Angeles , USA , was published in the “Journal of the American Medical Association” in 1995. It concludes: ”These results indicate an association between supplementary vitamin E intake and angiographically demonstrated reduction in coronary artery lesion progression” (Annexure ‘JAMA 1995’).
    2. “The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure”.
      This double-blind, placebo-controlled clinical study was conducted as a joint study at leading academic institutions, around the world, including the “National Heart and Lung Institute” (USA), “Imperial College School of Medicine”, (UK), the Department of Academic Cardiology, Castle Hill Hospital, (UK) and the “Charité Medical School” (Germany). It was published in the leading journal of clinical cardiology in Europe , the “European Heart Journal” in 2005. The study documents the benefits of micronutrients supplementation in patients with heart failure and concludes that the “left ventricular ejection fraction“ (i.e. the pumping function) of the heart can be improved by “long-term multiple micronutrients supplementation.” (Annexure ‘Eur Heart J’).
    3. “Effect of vitamins C and E on progression of transplant-associated atherosclerosis: a randomized trial.”
      This double-blind, placebo-controlled study published in “The Lancet” in 2002 concluded: “Supplementation with antioxidant vitamins C and E retards the early progression of transplant-associated coronary arteriosclerosis.” (Annexure ‘Lancet 2002’).
    4. “Dietary antioxidants and the risk of ischemic stroke.”
      This double-blind, placebo-controlled study included more than 5000 participants followed over more than six years. It concluded that ”high dietary intake of antioxidants, in particular, vitamin C and – in smokers – vitamin E, reduces the risk of stroke” (Annexure ‘Neurology’).