Ascorbate stabilizes the differentiated state and reduces the ability of Rous sarcoma virus to replicate and to uniformly transform cell cultures.
Am J Clin Nutr 1991 Dec;54(6 Suppl):1247S-1251S (ISSN: 0002-9165)
Cell and Molecular Biology Division, Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
In primary avian tendon cells, Rous sarcoma virus can coexist or completely
take over the cell. Infection, at high multiplicity or under conditions
that promote high virus production (no ascorbate and high serum concentrations),
results in almost complete oncogenic transformation of the culture. This
is indicated in part by a radical change in morphology, growth at high
cell density, and a dramatic drop in the production of procollagen from
approximately 50% to approximately 3% of total protein synthesis. In contrast,
infection at low multiplicity, infection with a replication defective
virus, or the presence of ascorbate restrict the ability of the virus
to transform the culture. Thus, there appears to be a balance between
the normal and transformed states of the cell that can be shifted depending
on the cellular environment and the level of infection. Ascorbate stabilizes
the normal state by reducing virus production and promoting the synthesis
of differentiated proteins.
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