The Scientific Breakthrough

Dr. Rath's research represents one of the great advances in biological defence against cancer. His findings can be summarised as follows:

• All types of cancer, irrespective of which organ they start in, spread by the same means: they use biological cutting tools (enzymes) that are capable of cutting through the surrounding collagen connective tissue.
   
• The natural amino acid lysine, especially in combination with vitamin C and other selected cellular nutrients, is capable of blocking this ‘collagen digestion'. Thus we have a biological mechanism that can prevent the spread of cancer cells – and therefore cancer itself.
   
• At Dr. Rath's Research Institute for Cellular Medicine in Santa Clara, California, large-scale test sequences have shown that all cancer types can be combated with the help of this biological principle.

These research results have been presented at numerous conferences of American and European cancer associations and published in professional journals.

More information on the natural eradication of cancer...

Scientific studies by Dr. Rath and his team

These research results have been presented at numerous conferences of American and European cancer associations and published in professional journals.

Effect Of Nutrient Synergy on Human Osteosarcoma Cells U-2OS
M.Waheed Roomi, Vadim Ivanov, Matthias Rath and Aleksandra Niedzwiecki

Antitumor Effect of an anti-cancer nutrient synergy in Pancreatic Cancer Cell Line MIA Pa Ca-2
M.W. Roomi, V. Ivanov, M. Rath, and A. Niedzwiecki
Matthias Rath, Inc., Research and Development, Santa Clara, CA 95050

A Specific Combination Of Ascorbic Acid, Lysine, Proline And Epigallocatechin Gallate Inhibits Proliferation And Extracellular Matrix Invasion Of Various Human Cancer Cell Lines
Shrirang P Netke, M Waheed Roomi, Vadim Ivanov, Aleksandra Niedzwiecki* and Matthias Rath
Matthias Rath, Inc., Research and Development, Santa Clara, CA 95054

Cytotxic Effect of Lipophlic Substitution at 2-, 6-, and 2,6-Positions in Ascorbic Acid and Expression of Matrix Metalloproteinases in Hep G2 Cells, Melanoma Cells and Norman Human Dermal Fibroblast.
M.W. Roomi, S. Netke, V. Ivanov, A. Niedzwiecki and M. Rath
J. Am. Coll. Nutr. 20: 43, 2001

Inhibitory effects of ascorbic acid, proline and lysine supplementation on Matrigel invasion by human breast cancer cells, MDA-MB231.
S Netke, Ph.D., V Ivanov , MD. Ph.D., W. Roomi, Ph. D., A Niedzwiecki, Ph. D., Matthias Rath, M.D.
Presented at: 19th Annual Miami Breast Cancer Conference, Miami Beach, Florida, February 27 – March 3, 2002. Published in: Conference Proceedings

Cellular Medicine Research Breakthroughs in the Control of Diseases: Report on Scientific Research
S Netke, Ph.D., V Ivanov , MD. Ph.D., W. Roomi, Ph. D., A Niedzwiecki, Ph. D., Matthias Rath, M.D.
Presented at: 21st Century Medical Advances in the Treatment of Cancer and Aging, Miami , Fl, March 22-24, 2003; Published in: Conference Proceedings

Nutritional supplement program halts progression of early coronary atherosclerosis.
M. Rath, M.D.
Controversies in Cardiovascular Nutrition, Stanford University Medical Center, Stanford, CA, May 4, 2002

Metastatic and Cytotoxic Effects of Ascorbigen and iso-Ascorbigen in Human Cancer Cell Lines.
M.W. Roomi, A. Bogale, V. Ivanov, S. Netke, A. Niedzwiecki and M. Rath
J. Am. Coll. Nut. 21: 54, 2002

Matrix Metalloproteinase-2 Inhibition and Invasion Potential in Human Chondrocytes by a natural anti-cancer formula - a Specific Mixture of Nutrients Containing Lysine, Proline, Ascorbic Acid and Epigallocatechin Gallate.
M.W. Roomi, S.P. Netke, V. Ivanov, M. Rath and A. Niedzwiecki
Presented at: American Association of Cancer Research Special Conference in Cancer Research: Proteases, Extracellular Matrix and Cancer, Hilton Head Island, South Carolina, Oct 9-13, 2002.

A Natural Anti-Cancer Formula - A Specific Formulation of Nutrients Containing Lysine,Proline, Ascorbic Acid, and Epigallocatechin Gallate Inhibits Matrix Metalloproteinases Activity and Invasion Potential of Human Cancer Cell Lines.
M.W. Roomi, S.P. Netke, V. Ivanov, M. Rath and A. Niedzwiecki
Presented at: European Organization for Research and Treatment of Cancer (EORTC), AACR and NCI Symposium on Molecular Targets and Cancer Therapeutics, Frankfurt, Germany, Nov 19-22, 2002; Published in: European Cancer Journal, 38, Suppl.7/Abs.280, 2002

Antitumorigenic Activity of a Natural Anti-Cancer Formula in Human Breast Cancer Lines MDA-MB-231 and MCF-7.
Roomi, M.W., Ivanov, V., Rath, M. and Niedzwiecki, A.
Presented at: The 8th Annual Multidisciplinary Symposium on Breast Disease, Amelia Island, FL, February 13-16, 2003; Published in: Conference Proceedings

A novel in vitro bioassay for screening matrix metalloproteinases activity in human cancer cell lines
M Waheed Roomi, Shirang P Netke, Vadim Ivanov, Matthias Rath and Aleksandra Niedzwiecki
Proceedings of the American Association for Cancer Research 44:4559(2003)

Inhibitory Effect of a Natural Anti-Cancer Formula - A Specific Formulation of Nutrients Containing Lysine, Proline, Ascorbic Acid and Epigallocatechin Gallate on the Matrix Metalloproteinases Activities and Invasion of Human Fibrosarcoma HT-1080 Cells
MW Roomi, V Ivanov, SP Netke, M Rath and A Niedzwiecki
FASEB Journal (2003) 8452

Aging affects expression of 70-kDa heat shock proteins in Drosophila.
J Biol Chem 1991 May 15;266(14):9332-8   
Niedzwiecki A; Kongpachith AM; Fleming JE

Expression of bovine superoxide dismutase in Drosophila melanogaster augments resistance of oxidative stress.
Mol Cell Biol 1991 Feb;11(2):632-40   
Reveillaud I; Niedzwiecki A; Bensch KG; Fleming JE

Changes in superoxide dismutase and catalase in aging heat-shocked Drosophila.
Free Radic Res Commun 1992;17(6):355-67   
Niedzwiecki A; Reveillaud I; Fleming JE

Role of oxidative stress in Drosophila aging.
Mutat Res 1992 Sep;275(3-6):267-79   
Fleming JE; Reveillaud I; Niedzwiecki A

Heat shock induces changes in the expression and binding of ubiquitin in senescent Drosophila melanogaster.
Dev Genet 1993;14(1):78-86
Niedzwiecki A; Fleming JE

Mechanistic aspects of ascorbate inhibition of human immunodeficiency virus.
Chem Biol Interact 1994 Jun;91(2-3):207-15   
Harakeh S; Niedzwiecki A; Jariwalla RJ

Ascorbate affects proliferation of guinea-pig vascular smooth muscle cells by direct and extracellular matrix-mediated effects.
J Mol Cell Cardiol 1997 Dec;29(12):3293-303   
Ivanov VO; Ivanova SV; Niedzwiecki A

Transforming growth factor-beta 1 and ascorbate regulate proliferation of cultured smooth muscle cells by independent mechanisms.
Atherosclerosis 1998 Sep;140(1):25-34   
Ivanov VO; Rabovsky AB; Ivanova SV; Niedzwiecki A

Porphyria-inducing activity of a series of pyridine and dihydropyridine compounds. Investigation in a cell culture system.
J Med Chem 1975 May;18(5):457-60
Roomi MW

The action of trypsin on central and peripheral nerve myelin.
Adv Exp Med Biol 1978;100:307-28
Eylar EH; Roomi MW

The PO protein. The major glycoprotein of peripheral nerve myelin.
Biochim Biophys Acta 1978 Sep 26;536(1):112-21   
Roomi MW; Ishaque A; Khan NR; Eylar EH

Isolation of a product from the trypsin-digested glycoprotein of sciatic nerve myelin.
Biochim Biophys Acta 1978 Sep 26;536(1):122-33   
Roomi MW; Eylar EH

The PO glycoprotein of peripheral nerve myelin.
Can J Biochem 1980 Oct;58(10):913-21   
Ishaque A; Roomi MW; Szymanska I; Kowalski S; Eylar EH

Effects of phenobarbital upon triacylglycerol metabolism in the rabbit.
Biochem J 1980 Oct 15;192(1):165-75   
Goldberg DM; Roomi MW; Yu A; Roncari DA

Effects of phenobarbital upon triacylglycerol metabolism in the guinea pig.
Can J Biochem 1981 Jan;59(1):48-53   
Goldberg DM; Yu A; Roomi MW; Roncari DA

Enzyme induction and hepatic glycerolipid synthesis in rats treated with 3-methylcholanthrene.
Can J Biochem 1981 Sep;59(9):793-8   
Goldberg DM; Roomi MW; Yu A; Roncari DA

Modulation by phenobarbital of lipolytic activity in postheparin plasma and tissues of the rat.
Can J Biochem 1982 Nov;60(11):1077-83   
Goldberg DM; Roomi MW; Yu A

Age-related changes in hepatic triacylglycerol content and phosphatidate phosphohydrolase activities in fasting male and female rats.
Enzyme 1983;30(1):59-65   
Goldberg DM; Roomi MW; Yu A

Growth suppression of malignant leukemia cell line in vitro by ascorbic acid (vitamin C) and its derivatives.
Cancer Lett 1998 Jan 9;122(1-2):93-9   
Roomi MW; House D; Eckert-Maksic M; Maksic ZB; Tsao CS

Cytotoxic effect of substitution at 2-, 6-, and 2,6-positions in ascorbic acid on malignant cell line.
Cancer Biochem Biophys 1998 Nov;16(4):295-300   
Roomi MW; House D; Tsao CS

Modulation of drug metabolizing enzymes in guinea pig liver by high intakes of ascorbic acid.
Int J Vitam Nutr Res 1998;68(1):42-7   
Roomi MW; Netke S; Tsao C

Association between hyperlipidemia and hepatic cytochrome P-450 in guinea pigs.
Res Commun Mol Pathol Pharmacol 1997 Aug;97(2):139-50   
Roomi MW

Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Xenobiotica 1997 Sep;27(9):951-60   
Roomi MW; Farber E; Parke DV

Ascorbic acid deficiency decreases the expression of CYP4A1 in liver microsomes of guinea pigs.
Res Commun Mol Pathol Pharmacol 1997 Jan;95(1):3-10   
Roomi MW; Ogg M; Tsao CS; Gibson GG

Ascorbic acid protects guinea pigs from acute aflatoxin toxicity.
Toxicol Appl Pharmacol 1997 Apr;143(2):429-35   
Netke SP; Roomi MW; Tsao C; Niedzwiecki A

Modulation of synovial fibroblast plasminogen activator and plasminogen activator inhibitor production by protein kinase C.
Biochim Biophys Acta 1991 Nov 21;1097(4):283-8
Uhl J; Newton RC; Gross JL; Rommi W; Mochan E

Kinetics of excretion of 2-acetylaminofluorene in normal and xenobiotic-treated rats and in rats with hepatocyte nodules.
Lab Invest 1989 Mar;60(3):399-408   
Rinaudo JA; Eriksson LC; Roomi MW; Farber E

Modulation of the activity of hepatic gamma-glutamyl transpeptidase, adenosine triphosphatase, placental glutathione S-transferase and adenylate cyclase by acute administration of lead nitrate.
Basic Appl Histochem 1988;32(4):501-10
Columbano A; Ledda-Columbano GM; Ennas MG; Curto M; De Montis MG; Roomi MW; Pani P; Sarma DS

Decreased cytosolic levels of the heme binding Z protein in rat hepatocyte nodules and hepatocellular carcinomas.
Cancer Lett 1988 Dec 1;43(1-2):55-8   
Roomi MW; Vincent SH; Farber E; Muller-Eberhard U

The galactosyltransferase activity of hepatic nodules during rat liver carcinogenesis.
Cancer Lett 1988 Dec 1;43(1-2):49-54   
Roomi MW; Mitranic MM; Farber E; Moscarello MA

Glutathione and enzymes related to free radical metabolism in liver of rats fed a choline-devoid low-methionine diet.
Cancer Lett 1988 Jul;41(1):53-62
Ghoshal A; Roomi MW; Ahluwalia M; Simmonds W; Rushmore TH; Farber E; Ghoshal AK

Decreased expression of cytochrome P-452 in the resistance phenotype characteristic of putative preneoplastic hepatocyte nodules during hepatocarcinogenesis.
Biochem Biophys Res Commun 1988 Apr 29;152(2):921-5   
Roomi MW; Bacher MA; Gibson GG; Parke DV; Farber E

Induction of the placental form of glutathione S-transferase by lead nitrate administration in rat liver.
Toxicol Pathol 1987;15(2):202-5   
Roomi MW; Columbano A; Ledda-Columbano GM; Sarma DS

Identification of a characteristic cytosolic polypeptide of rat preneoplastic hepatocyte nodules as placental glutathione S-transferase.
Biochem Biophys Res Commun 1987 Feb 27;143(1):98-103
Rushmore TH; Sharma RN; Roomi MW; Harris L; Satoh K; Sato K; Murray RK; Farber E

Lead nitrate induces certain biochemical properties characteristic of hepatocyte nodules.
Carcinogenesis 1986 Oct;7(10):1643-6
Roomi MW; Columbano A; Ledda-Columbano GM; Sarma DS

Changes in progesterone binding and metabolism in liver microsomes from persistent hepatocyte nodules and hepatomas in male rats.
Cancer Res 1986 Jan;46(1):76-80   
Feuer G; Stuhne-Sekalec L; Roomi MW; Cameron RG

Association between progesterone binding and cytochrome P-450 content of hepatic microsomes in the rat treated with cobalt-haem.
Xenobiotica 1985 May;15(5):407-12   
Feuer G; Waheed Roomi M; Stuhne-Sekalec L; Cameron RG

A common biochemical pattern in preneoplastic hepatocyte nodules generated in four different models in the rat.
Cancer Res 1985 Feb;45(2):564-71   
Roomi MW; Ho RK; Sarma DS; Farber E

Chemical carcinogenesis: hepatocyte nodules with a special phenotype as a common step at the crossroads.
Toxicol Pathol 1984;12(3):288-90   
Farber E; Eriksson LC; Roomi MW; Cameron RG; Hayes MA

Comparative influences of different PB-type and 3-MC-type polychlorinated biphenyl-induced phenotypes on cytocidal hepatotoxicity of bromobenzene and acetaminophen.
Toxicol Appl Pharmacol 1984 Oct;76(1):118-27   
Hayes MA; Roberts E; Roomi MW; Safe SH; Farber E; Cameron RG

Orotic acid, a new promoter for experimental liver carcinogenesis.
Toxicol Pathol 1984;12(2):173-8   
Rao PM; Nagamine Y; Roomi MW; Rajalakshmi S; Sarma DS

A characteristic electrophoretic pattern of cytosolic polypeptides from hepatocyte nodules generated during liver carcinogenesis in several models.
Biochem Biophys Res Commun 1983 Dec 28;117(3):740-5   
Eriksson LC; Sharma RN; Roomi MW; Ho RK; Farber E; Murray RK