Glucosamine sulfate, Chondroitin sulfate
"Anti-arthrosis treatments: efficacy and tolerance of chondroitin
sulfates
(CS 4&6)"
Conrozier T; Presse Med 1998 Nov 21;27(36):1862-5. CHONDROPROTECTIVE
DRUGS: Long-acting chondroprotective drugs have a symptomatic effect.
They are only effective in subjects with osteoarthritis and have no pure
pain relieving effect. They act within several weeks, improve functional
manifestations and have a remnant effect.
CHONDROITIN SULFATES 4&6: CS 4&6 are glycosaminoglycans which
participate in the matrix structure of cartilage. They are well absorbed
after oral intake. They have a dose-dependent inhibitor effect in vitro
on proteoglycan and collagen catabolism and have been shown to stimulate
matrix synthesis. Several clinical studies have demonstrated the chondroprotective
efficacy of CS 4&6 in osteoarthritis involving the hip, knee and finger
joints.
OSTEOARTHRITIS OF THE KNEE: A controlled randomized double-blind study
versus placebo was conducted in 104 patients with femorotibial osteoarthritis.
The objective was to demonstrate that CS 4&6 given orally in a sequential
regimen at the dose of 800 mg/d has a beneficial effect both in terms
of clinical manifestations and in terms of the anatomic progression in
patients with osteoarthritis of the knee. The main efficacy criteria was
the Lequesne functional score. After 1 year of treatment with CS 4&6,
the functional impairment was reduced by approximately 50%, a significant
improvement over placebo for all clinical criteria. Tolerance was excellent
or good in more than 90% of the cases.
A STRUCTURE MODULATOR: This study suggests that chondroitin sulfates
act as structure modulators as shown by the improvement in the interarticular
space visualized on the x-rays of patients treated with CS 4&6.
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