ALZHEIMER'S DISEASE - DEMENTIA, VITMIN C, ASCORBIC ACID, DEHYDROASCORBATE, FREE RADICALS
"Ascorbic Acid in Cerebrospinal Fluid – A Possible Protection Against Free Radicals in the Brain"
Barabas, Judit, et al, Archives of Gerontology and Geriatrics, 1995;21:43-48.
Ascorbic acid and dehydroascorbate levels in the plasma and CSF of 12
patients with senile dementia of moderate grade Alzheimer's type were
found to be significantly lower than 15 young, healthy volunteers. An
intravenous infusion of 2 gm of ascorbic acid in 5 of these patients showed
an active transport process for vitamin C from the plasma through the
blood-CSF barrier. The study confirmed the free radical scavenging
function of ascorbic acid in the central nervous system. Monitoring
ascorbic acid levels in the plasma of demented patients is recommended
because of its protective role in the free radical process that occurs
in dementia. The amyloid precursor proteins aggregate only in the presence
of free radicals. Vitamin C may reduce the harmful effects of
free radicals in the brain.
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