Serum vitamin A and beta-carotene levels in pregnant women infected with human immunodeficiency virus-1.
Obstetrics and gynecology; VOL: 87 (4); p. 564-7
Phuapradit W; Chaturachinda K; Taneepanichskul S; Sirivarasry J; Khupulsup K; Lerdvuthisopon N
OBJECTIVE: To determine if low levels of serum vitamin A and beta-carotene are present in pregnant women with human immunodeficiency virus-1 (HIV-1) infection. METHODS: Serum concentrations of vitamin A and beta-carotene were measured in 74 pregnant women seropositive for HIV-1 infection (17 with CD4 count below 200 cells/microliter) and in 148 pregnant seronegative controls in the first trimester. Comparisons were made between groups stratified by CD4 count. RESULTS: Compared with controls, women with HIV-1 infection and CD4 count below 200 cells/microliter exhibited 37% lower mean serum vitamin A levels (0.820 versus 1.308 micromol/L, P < .001) and 37% lower mean serum beta-carotene levels (1.486 versus 2.362 micromol/L, P < .001). Mean maternal age, parity, gestational age, hemoglobin levels, and body mass index at entry into the study did not differ significantly between the control and HIV-1 infection groups. In addition, serum vitamin A levels correlated significantly with the percentage of CD4 lymphocytes (r = 0.589, P < .001), CD4 count (r = 0.772, P < .001), and CD4 to CD8 ratio (r = 0.593, P < .001). Serum beta-carotene levels correlated with the percentage of CD4 lymphocytes (r = 0.407, P < .001), CD4 count (r = 0.614, P < .001), and CD4 to CD8 ratio (r = 0.434, P < .001). CONCLUSION: Compared with levels in uninfected women, serum vitamin A and beta-carotene are decreased in HIV-1-infected pregnant women in the first trimester with CD4 counts lower than 200 cells/microliter. These micronutrient concentrations also correlate with CD4 count.
- Death Of David Rockefeller At 101: Media Obituaries Ignore His Central Role In Bilderberg Group
- Study Finds High-Dose B Vitamins Have Protective Effect Against Air Pollution
- LESSONS FROM HISTORY: Thomas Müntzer – Violent Revolution Is Never The Answer
- The Importance of Micronutrients for Healthy Hair
- MORE Bad News For Pharma: Bisphosphonate Drugs For Osteoporosis WEAKEN Bones!
- Worldwide Studies Show High-Dose B Vitamins Reduce Schizophrenia Symptoms
- U.S. Department Of Defense Revealed To Be Editing Wikipedia